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Allergy medicines (antihistamines)

Diphenhydramine

Also sold as: Benadryl

No prescription neededAllergy medicines (antihistamines)
Comes as:TabletCapsuleSyrupInjection

Usual adult dose

Usual adult dose: 25 to 50 mg every 4 to 6 hours when needed. Do not take more than 300 mg in 24 hours. Not for children under 6 years unless a doctor advises.

Your doctor may give you a different dose. Children's doses depend on weight.

Side effects

Common

  • strong drowsiness
  • dry mouth
  • dizziness
  • blurred vision
  • constipation

Serious — get help

Stop taking it and see a doctor straight away if you notice:

  • confusion or hallucinations
  • fits
  • fast or irregular heartbeat
  • inability to pass urine
  • severe allergic reaction

Do not take it, or take care, if

  • Glaucoma (raised eye pressure)
  • Enlarged prostate or difficulty passing urine
  • Young children and elderly people (use with caution)
  • Do not drive or use machines; avoid alcohol
  • Breastfeeding

Interactions

Medicines that can react with this one.

Moderate3 medicinesTake together only with care. Ask your doctor or pharmacist.
  • Amitriptyline

    Both have anticholinergic effects; more dry mouth, constipation, confusion and urine retention.

  • Diazepam

    Together they cause more drowsiness and slowed reactions.

  • Morphine

    Combined use increases drowsiness and the risk of slowed breathing.

Pregnancy

  1. A
  2. B
  3. C
  4. D
  5. X

Category B

No risk seen in animal studies, but there are few studies in pregnant women. Usually considered safe when needed.

Generic alternatives

Similar medicines your doctor or pharmacist may offer instead.

  • ChlorphenamineNo prescription needed
  • Promethazine
  • CetirizineNo prescription needed
Check with my other medicines

Always follow your doctor or pharmacistThis page is general information, not a prescription. Do not start, stop or change a medicine on your own.