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Arthritis and immune medicines

Hydroxychloroquine

Also sold as: Plaquenil, HCQS

Prescription neededArthritis and immune medicines
Comes as:Tablet

Usual adult dose

Usual adult dose for arthritis or lupus: 200 to 400 mg a day with food, not more than 5 mg per kg body weight a day. Regular eye checks are needed with long-term use.

Your doctor may give you a different dose. Children's doses depend on weight.

Side effects

Common

  • nausea
  • stomach upset
  • diarrhoea
  • headache
  • skin rash

Serious — get help

Stop taking it and see a doctor straight away if you notice:

  • changes in vision
  • fainting or very fast or irregular heartbeat
  • low blood sugar
  • severe skin rash

Do not take it, or take care, if

  • Existing eye (retina) disease
  • Heart rhythm problems or taking other medicines that affect heart rhythm
  • G6PD deficiency, liver or kidney disease (use with caution)
  • Keep out of reach of children — overdose is very dangerous

Interactions

Medicines that can react with this one.

Serious1 medicineDo not take these together unless your doctor says so.
  • Amiodarone

    Both prolong the QT interval; together they raise the risk of dangerous heart rhythms.

Moderate2 medicinesTake together only with care. Ask your doctor or pharmacist.
  • Azithromycin

    Both can prolong the QT interval; use together with caution.

  • Digoxin

    Hydroxychloroquine can raise digoxin levels; levels may need checking.

Pregnancy

  1. A
  2. B
  3. C
  4. D
  5. X

Category C

A risk to the baby cannot be ruled out. Use only if your doctor says the benefit is greater than the risk.

Generic alternatives

Similar medicines your doctor or pharmacist may offer instead.

  • Methotrexate
  • Sulfasalazine
  • Chloroquine
Check with my other medicines

Always follow your doctor or pharmacistThis page is general information, not a prescription. Do not start, stop or change a medicine on your own.