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Blood thinners

Apixaban

Also sold as: Eliquis

Prescription neededBlood thinners
Comes as:Tablet

Usual adult dose

Atrial fibrillation: 5 mg twice a day (2.5 mg twice a day in some elderly or kidney patients). Treatment of clots: 10 mg twice a day for 7 days, then 5 mg twice a day. Do not stop without your doctor.

Your doctor may give you a different dose. Children's doses depend on weight.

Side effects

Common

  • bruising
  • nosebleeds
  • bleeding gums
  • nausea

Serious — get help

Stop taking it and see a doctor straight away if you notice:

  • black stools
  • blood in urine
  • vomiting blood
  • severe headache
  • bleeding that does not stop

Do not take it, or take care, if

  • Active bleeding
  • Severe liver disease
  • Pregnancy and breastfeeding
  • Artificial (mechanical) heart valve

Interactions

Medicines that can react with this one.

Serious3 medicinesDo not take these together unless your doctor says so.
  • Aspirin

    Together they greatly raise the risk of serious bleeding.

  • Ketoconazole

    Ketoconazole tablets raise apixaban levels and the risk of bleeding; avoid.

  • Rifampicin

    Rifampicin lowers apixaban levels so it may not prevent clots; avoid.

Moderate1 medicineTake together only with care. Ask your doctor or pharmacist.
  • Clopidogrel

    Together they raise the risk of bleeding.

Pregnancy

  1. A
  2. B
  3. C
  4. D
  5. X

Category B

No risk seen in animal studies, but there are few studies in pregnant women. Usually considered safe when needed.

Generic alternatives

Similar medicines your doctor or pharmacist may offer instead.

  • Rivaroxaban
  • Warfarin
  • Enoxaparin
Check with my other medicines

Always follow your doctor or pharmacistThis page is general information, not a prescription. Do not start, stop or change a medicine on your own.