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Other stomach and liver medicines

Mesalazine

Also sold as: Asacol, Pentasa, Salofalk

Prescription neededOther stomach and liver medicines
Comes as:TabletSachetSuppository

Usual adult dose

Dose is set by your doctor and depends on the product. For active ulcerative colitis usually 2.4 to 4.8 g a day by mouth, then a lower dose to keep it in remission. Swallow tablets whole. Suppositories are used for disease in the rectum.

Your doctor may give you a different dose. Children's doses depend on weight.

Side effects

Common

  • headache
  • nausea
  • stomach pain
  • diarrhoea
  • rash

Serious — get help

Stop taking it and see a doctor straight away if you notice:

  • unexplained bruising
  • bleeding
  • sore throat or fever (blood problem)

Do not take it, or take care, if

  • Allergy to aspirin or other salicylates
  • Severe kidney or liver disease
  • Blood tests and kidney tests are needed during treatment

Interactions

Medicines that can react with this one.

Moderate1 medicineTake together only with care. Ask your doctor or pharmacist.
  • Azathioprine

    Mesalazine can increase the risk of low blood counts with azathioprine; blood tests are needed.

Pregnancy

  1. A
  2. B
  3. C
  4. D
  5. X

Category B

No risk seen in animal studies, but there are few studies in pregnant women. Usually considered safe when needed.

Generic alternatives

Similar medicines your doctor or pharmacist may offer instead.

chest pain or breathlessness (heart inflammation)
  • severe stomach pain (pancreatitis)
  • kidney problems
  • Minor1 medicineUsually not a problem, but tell your doctor.
    • Warfarin

      Mesalazine may reduce the effect of warfarin; INR should be checked.

    Sulfasalazine
    Check with my other medicines

    Always follow your doctor or pharmacistThis page is general information, not a prescription. Do not start, stop or change a medicine on your own.