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Arthritis and immune medicines

Azathioprine

Also sold as: Imuran, Azoran

Prescription neededArthritis and immune medicines
Comes as:Tablet

Usual adult dose

Dose is set by your specialist, usually 1 to 3 mg per kg body weight a day after food. Regular blood tests are needed.

Your doctor may give you a different dose. Children's doses depend on weight.

Side effects

Common

  • nausea
  • vomiting
  • loss of appetite
  • tiredness

Serious — get help

Stop taking it and see a doctor straight away if you notice:

  • sore throat
  • fever or signs of infection
  • unusual bleeding or bruising
  • severe stomach pain
  • yellow eyes or skin

Do not take it, or take care, if

  • Taking allopurinol or febuxostat (dangerous unless the doctor adjusts doses)
  • Live vaccines during treatment
  • Active serious infection or low blood counts
  • Pregnancy (only if a specialist decides)

Interactions

Medicines that can react with this one.

Serious2 medicinesDo not take these together unless your doctor says so.
  • Allopurinol

    Allopurinol greatly raises azathioprine levels and can cause severe bone marrow damage.

  • Febuxostat

    Febuxostat greatly raises azathioprine levels; do not use together.

Moderate4 medicinesTake together only with care. Ask your doctor or pharmacist.
  • Co-trimoxazole

    Together they increase the risk of low blood counts.

  • Mesalazine

    Mesalazine can increase the risk of low blood counts with azathioprine; blood tests are needed.

  • Sulfasalazine

    Together they increase the risk of low blood counts; blood tests are needed.

  • Warfarin

    Azathioprine can reduce the effect of warfarin; INR should be checked.

Pregnancy

  1. A
  2. B
  3. C
  4. D
  5. X

Category D

There is evidence of risk to the baby. Used only in serious situations when safer medicines do not work.

Generic alternatives

Similar medicines your doctor or pharmacist may offer instead.

  • Methotrexate
Check with my other medicines

Always follow your doctor or pharmacistThis page is general information, not a prescription. Do not start, stop or change a medicine on your own.