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Water pills (diuretics)

Hydrochlorothiazide

Also sold as: Esidrex

Prescription neededWater pills (diuretics)
Comes as:Tablet

Usual adult dose

Usual adult dose: 12.5 to 25 mg once a day in the morning (up to 50 mg).

Your doctor may give you a different dose. Children's doses depend on weight.

Side effects

Common

  • passing more urine
  • dizziness
  • thirst
  • muscle cramps

Serious — get help

Stop taking it and see a doctor straight away if you notice:

  • very low sodium or potassium (confusion
  • severe weakness
  • irregular heartbeat)
  • gout attack
  • severe skin rash
  • sudden eye pain or blurred vision

Do not take it, or take care, if

  • Severe kidney or liver disease
  • Low potassium or sodium
  • Gout (use with caution)
  • Diabetes (can raise blood sugar; use with caution)

Interactions

Medicines that can react with this one.

Serious1 medicineDo not take these together unless your doctor says so.
  • Lithium carbonate

    Thiazide diuretics raise lithium levels and the risk of toxicity.

Moderate2 medicinesTake together only with care. Ask your doctor or pharmacist.
  • Digoxin

    Low potassium from the diuretic raises the risk of digoxin toxicity.

  • Ibuprofen

    NSAIDs reduce the effect of the diuretic and can harm the kidneys.

Pregnancy

  1. A
  2. B
  3. C
  4. D
  5. X

Category B

No risk seen in animal studies, but there are few studies in pregnant women. Usually considered safe when needed.

Generic alternatives

Similar medicines your doctor or pharmacist may offer instead.

  • Chlortalidone
  • Indapamide
Check with my other medicines

Always follow your doctor or pharmacistThis page is general information, not a prescription. Do not start, stop or change a medicine on your own.