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Steroids (corticosteroids)

Methylprednisolone

Also sold as: Solu-Medrol, Medrol

Prescription neededSteroids (corticosteroids)
Comes as:TabletInjection

Usual adult dose

Dose is set by your doctor; tablets are usually 4 to 48 mg a day depending on the illness. High-dose injections are given only in hospital. Do not stop suddenly after long use.

Your doctor may give you a different dose. Children's doses depend on weight.

Side effects

Common

  • increased appetite
  • mood changes
  • trouble sleeping
  • stomach irritation
  • high blood sugar

Serious — get help

Stop taking it and see a doctor straight away if you notice:

  • black stools or vomiting blood
  • signs of serious infection
  • severe mood change
  • blurred vision

Do not take it, or take care, if

  • Untreated serious infection (including active TB) unless a doctor is treating it
  • Live vaccines during high-dose treatment
  • Diabetes, high blood pressure, stomach ulcer or glaucoma (use with caution)
  • Do not stop suddenly after long use

Interactions

Medicines that can react with this one.

Moderate3 medicinesTake together only with care. Ask your doctor or pharmacist.
  • Clarithromycin

    Clarithromycin raises methylprednisolone levels and steroid side effects.

  • Ibuprofen

    Steroids with NSAIDs raise the risk of stomach ulcers and bleeding.

  • Rifampicin

    Rifampicin makes methylprednisolone work less well.

Pregnancy

  1. A
  2. B
  3. C
  4. D
  5. X

Category C

A risk to the baby cannot be ruled out. Use only if your doctor says the benefit is greater than the risk.

Generic alternatives

Similar medicines your doctor or pharmacist may offer instead.

  • Prednisolone
  • Dexamethasone
  • Triamcinolone
Check with my other medicines

Always follow your doctor or pharmacistThis page is general information, not a prescription. Do not start, stop or change a medicine on your own.