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Macrolides

Clarithromycin

Also sold as: Klaricid, Biaxin

Prescription neededMacrolides
Comes as:TabletSuspension

Usual adult dose

Usual adult dose: 250 to 500 mg twice a day, usually for 7 to 14 days. Finish the full course.

Your doctor may give you a different dose. Children's doses depend on weight.

Side effects

Common

  • nausea
  • stomach pain
  • diarrhoea
  • metallic or bitter taste
  • headache

Serious — get help

Stop taking it and see a doctor straight away if you notice:

  • severe allergic reaction
  • fast or irregular heartbeat or fainting
  • yellow eyes or skin
  • severe or bloody diarrhoea

Do not take it, or take care, if

  • Allergy to macrolide antibiotics
  • Heart rhythm problems (long QT)
  • Severe liver disease
  • Taking simvastatin or colchicine
  • Pregnancy (only if a doctor decides it is needed)

Interactions

Medicines that can react with this one.

Serious14 medicinesDo not take these together unless your doctor says so.
  • Alprazolam

    Clarithromycin raises alprazolam levels and sedation.

  • Amiodarone

    Both can prolong the QT interval and cause dangerous heart rhythms.

  • Atorvastatin

    Clarithromycin raises atorvastatin levels and the risk of muscle damage.

  • Carbamazepine

    Clarithromycin raises carbamazepine levels and can cause toxicity.

  • Colchicine

    Can cause life-threatening colchicine toxicity; avoid together.

  • Dihydroartemisinin + Piperaquine

    Raises piperaquine levels and adds to QT prolongation; avoid together.

Show 8 more
  • Domperidone

    Raises domperidone levels and prolongs the QT interval; do not combine.

  • Fluticasone + Salmeterol

    Clarithromycin raises salmeterol levels and can cause heart rhythm problems; avoid the combination.

  • Methylergometrine

    Clarithromycin raises methylergometrine levels and can cause dangerous narrowing of blood vessels.

  • Midazolam

    Clarithromycin greatly raises midazolam levels and prolongs sedation.

  • Quetiapine

    Clarithromycin greatly raises quetiapine levels; avoid together.

  • Simvastatin

    Greatly raises simvastatin levels and the risk of severe muscle damage; do not combine.

Moderate8 medicinesTake together only with care. Ask your doctor or pharmacist.
  • Amlodipine

    Clarithromycin raises amlodipine levels and can cause low blood pressure.

  • Aripiprazole

    Clarithromycin raises aripiprazole levels.

  • Digoxin

    Clarithromycin raises digoxin levels.

  • Loperamide

    Clarithromycin can raise loperamide levels.

Pregnancy

  1. A
  2. B
  3. C
  4. D
  5. X

Category C

A risk to the baby cannot be ruled out. Use only if your doctor says the benefit is greater than the risk.

Generic alternatives

Similar medicines your doctor or pharmacist may offer instead.

  • Azithromycin
  • Erythromycin
Check with my other medicines

Always follow your doctor or pharmacistThis page is general information, not a prescription. Do not start, stop or change a medicine on your own.

  • Theophylline

    Clarithromycin raises theophylline levels and can cause toxicity.

  • Warfarin

    Can strongly raise the effect of warfarin; INR must be checked.

  • Methylprednisolone

    Clarithromycin raises methylprednisolone levels and steroid side effects.

  • Solifenacin

    Clarithromycin raises solifenacin levels; the dose should not exceed 5 mg.

  • Show 2 more
    • Tamsulosin

      Clarithromycin raises tamsulosin levels and the risk of dizziness and low blood pressure.

    • Triamcinolone

      Clarithromycin can raise steroid levels after triamcinolone injection and increase side effects.