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Epilepsy and nerve pain

Carbamazepine

Also sold as: Tegretol

Prescription neededEpilepsy and nerve pain
Comes as:TabletSuspension

Usual adult dose

Usual adult dose: start with 100 mg to 200 mg once or twice a day; the doctor raises it slowly, usually to 400 mg to 1,200 mg a day. It is also used for trigeminal nerve pain. Do not stop it suddenly.

Your doctor may give you a different dose. Children's doses depend on weight.

Side effects

Common

  • dizziness
  • drowsiness
  • nausea
  • unsteady walking
  • double vision

Serious — get help

Stop taking it and see a doctor straight away if you notice:

  • severe skin rash with blisters or peeling
  • fever with sore throat or mouth ulcers
  • unusual bleeding or bruising
  • yellow eyes or skin
  • confusion (low blood sodium)

Do not take it, or take care, if

  • Bone marrow or blood disorders
  • Heart block
  • Pregnancy (can harm the baby — plan with your doctor)
  • Liver disease (use with caution)
  • Past severe skin rash with this or similar medicines

Interactions

Medicines that can react with this one.

Serious6 medicinesDo not take these together unless your doctor says so.
  • Clarithromycin

    Clarithromycin raises carbamazepine levels and can cause toxicity.

  • Daclatasvir

    Carbamazepine strongly lowers daclatasvir levels; do not combine.

  • Ethinylestradiol + Levonorgestrel

    Carbamazepine makes the contraceptive pill less effective; use another method.

  • Levonorgestrel

    Carbamazepine makes levonorgestrel less effective; ask a doctor about a double dose or a copper IUD.

  • Sofosbuvir

    Carbamazepine lowers sofosbuvir levels so treatment may fail.

  • Warfarin

    Carbamazepine lowers the effect of warfarin; INR must be checked.

Moderate15 medicinesTake together only with care. Ask your doctor or pharmacist.
  • Albendazole

    Carbamazepine lowers albendazole levels, which matters for long treatment of tissue worm infections.

  • Aripiprazole

    Carbamazepine lowers aripiprazole levels; the dose may need to be raised.

  • Clonazepam

    Carbamazepine lowers clonazepam levels.

  • Erythromycin

    Raises carbamazepine levels and can cause toxicity.

Minor1 medicineUsually not a problem, but tell your doctor.
  • Flunarizine

    Carbamazepine can lower flunarizine levels.

Pregnancy

  1. A
  2. B
  3. C
  4. D
  5. X

Category D

There is evidence of risk to the baby. Used only in serious situations when safer medicines do not work.

Generic alternatives

Similar medicines your doctor or pharmacist may offer instead.

  • Sodium valproate
  • Lamotrigine
  • Levetiracetam
  • Phenytoin
Check with my other medicines

Always follow your doctor or pharmacistThis page is general information, not a prescription. Do not start, stop or change a medicine on your own.

  • Haloperidol

    Carbamazepine lowers haloperidol levels, so it may work less well.

  • Isoniazid

    Isoniazid can raise carbamazepine levels.

  • Show 9 more
    • Lamotrigine

      Carbamazepine lowers lamotrigine levels.

    • Norethisterone

      Carbamazepine lowers norethisterone levels and can make it less effective.

    • Olanzapine

      Carbamazepine lowers olanzapine levels, so it may work less well.

    • Praziquantel

      Carbamazepine lowers praziquantel levels.

    • Progesterone

      Carbamazepine lowers progesterone levels and can make it less effective.

    • Quetiapine

      Carbamazepine strongly lowers quetiapine levels, so it may not work.

    • Risperidone

      Carbamazepine lowers risperidone levels, so it may work less well.

    • Sodium valproate

      Carbamazepine lowers valproate levels; levels should be checked.

    • Tramadol

      Carbamazepine lowers tramadol levels and both affect seizure risk; avoid together.