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Antifungals

Itraconazole

Also sold as: Sporanox, Canditral

Prescription neededAntifungals
Comes as:CapsuleOral solution

Usual adult dose

Usual adult dose: 100 to 200 mg once or twice a day, capsules taken right after a full meal. Length depends on the infection, for example 200 mg a day for 7 days for skin fungus.

Your doctor may give you a different dose. Children's doses depend on weight.

Side effects

Common

  • nausea
  • stomach pain
  • headache
  • rash

Serious — get help

Stop taking it and see a doctor straight away if you notice:

  • yellow eyes or skin
  • swelling of legs or breathlessness (heart failure)
  • severe skin rash
  • numbness of hands and feet

Do not take it, or take care, if

  • Heart failure
  • Pregnancy
  • Liver disease (use with caution)
  • Taking simvastatin

Interactions

Medicines that can react with this one.

Serious5 medicinesDo not take these together unless your doctor says so.
  • Alprazolam

    Itraconazole greatly raises alprazolam levels; avoid together.

  • Atorvastatin

Pregnancy

  1. A
  2. B
  3. C
  4. D
  5. X

Category C

A risk to the baby cannot be ruled out. Use only if your doctor says the benefit is greater than the risk.

Generic alternatives

Similar medicines your doctor or pharmacist may offer instead.

Itraconazole raises atorvastatin levels and the risk of muscle damage.

  • Midazolam

    Itraconazole greatly raises midazolam levels and prolongs sedation.

  • Rifampicin

    Rifampicin lowers itraconazole levels so much that it may not work.

  • Simvastatin

    Itraconazole greatly raises simvastatin levels and the risk of severe muscle damage; do not combine.

  • Moderate7 medicinesTake together only with care. Ask your doctor or pharmacist.
    • Budesonide

      Itraconazole raises budesonide levels and can cause steroid side effects.

    • Budesonide + Formoterol

      Itraconazole raises budesonide levels and can cause steroid side effects.

    • Famotidine

      Reduced stomach acid lowers absorption of itraconazole capsules.

    • Lansoprazole

      Reduced stomach acid lowers absorption of itraconazole capsules.

    • Loperamide

      Itraconazole raises loperamide levels and may increase side effects, including heart rhythm problems.

    • Omeprazole

      Stomach acid reducers lower absorption of itraconazole capsules.

    Show 1 more
    • Pantoprazole

      Reduced stomach acid lowers absorption of itraconazole capsules.

    Fluconazole
  • Terbinafine
  • Griseofulvin
  • Check with my other medicines

    Always follow your doctor or pharmacistThis page is general information, not a prescription. Do not start, stop or change a medicine on your own.