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Diabetes tablets

Gliclazide

Also sold as: Diamicron, Glizid

Prescription neededDiabetes tablets
Comes as:Tablet

Usual adult dose

Usual adult dose: 40 to 80 mg once or twice a day with meals (maximum 320 mg a day). Modified-release tablets: 30 to 120 mg once a day with breakfast.

Your doctor may give you a different dose. Children's doses depend on weight.

Side effects

Common

  • low blood sugar (shaking
  • sweating
  • hunger)
  • nausea
  • stomach upset
  • weight gain

Serious — get help

Stop taking it and see a doctor straight away if you notice:

  • severe low blood sugar (confusion
  • fits
  • unconsciousness)
  • yellow eyes or skin
  • severe skin rash

Do not take it, or take care, if

  • Type 1 diabetes or diabetic ketoacidosis
  • Severe kidney or liver disease
  • Pregnancy and breastfeeding (insulin is usually preferred)
  • Allergy to sulfonamide (sulfa) medicines
  • Elderly people and irregular meals (use with caution)

Interactions

Medicines that can react with this one.

Serious1 medicineDo not take these together unless your doctor says so.
  • Fluconazole

    Fluconazole raises gliclazide levels and can cause severe low blood sugar.

Moderate3 medicinesTake together only with care. Ask your doctor or pharmacist.
  • Co-trimoxazole

    Co-trimoxazole can increase the risk of low blood sugar.

  • Prednisolone

    Steroids raise blood sugar and reduce the effect of gliclazide.

  • Vildagliptin

    The combination increases the risk of low blood sugar; the gliclazide dose may need to be lowered.

Minor1 medicineUsually not a problem, but tell your doctor.
  • Pioglitazone

    The combination lowers blood sugar more; the sulfonylurea dose may need to be reduced.

Pregnancy

  1. A
  2. B
  3. C
  4. D
  5. X

Category C

A risk to the baby cannot be ruled out. Use only if your doctor says the benefit is greater than the risk.

Generic alternatives

Similar medicines your doctor or pharmacist may offer instead.

  • Glimepiride
  • Glibenclamide
  • Metformin
Check with my other medicines

Always follow your doctor or pharmacistThis page is general information, not a prescription. Do not start, stop or change a medicine on your own.